South Africa is enduring the world's largest HIV epidemic, with more than 5.7 million people infected. Grassroot Soccer (GRS) aims to dramatically reduce the spread of HIV in South Africa by rolling out a prevention campaign that, through the power of football, empowers young women with the knowledge, skills and support to live HIV free. Skillz Street combines a powerful HIV prevention and life skills curriculum (Generation Skillz) with an all-girls street soccer league emphasizing fair-play, teamwork, and community engagement. The intiative addresses the major social norms fueling South Africa's HIV epidemic: Intergenerational/Transactional Sex, Multiple Sexual Partner, Alcohol Abuse, and Gender Based Violence.